The described effect involves the inhibition of DYRK1A, which is located on chromosome 21 and is over activated in patients with Down syndrome and Alzheimer's Disease.ĭon't Miss: Epilepsy has been found to reduce the generation of new neurons Researchers were also able to identify how the human neural cells respond to harmine. After four days, harmine led to a 70% increase in proliferation of human neural progenitor cells. In order to elucidate these effects, researchers from the D'Or Institute for Research and Education and the Institute of Biomedical Sciences at the Federal University of Rio de Janeiro exposed human neural progenitors to this beta-carboline. So we decided to test if harmine, an alkaloid with the highest concentration in the psychotropic plant decoction ayahuasca, would trigger neurogenesis in human neural cells", said Vanja Dakic, PhD student and one of the authors in the study. "It has been shown in rodents that antidepressant medication acts by inducing neurogenesis. See Also: Healthy intestinal flora keeps the mind sharp-with some help from the immune system One of the main substances present in the beverage is harmine, a beta-carboline which potential therapeutic effects for depression has been recently described in mice. Studies suggest that it exhibits anxiolytic and antidepressant effects in humans. Brazilian study suggests that harmine increases the number of neural progenitors, cells that give rise to neurons -Īyahuasca is a powerful herbal beverage that has been used for centuries by Native South-Americans.
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